1 g of the drug contains the active substance: piperazine citrate – 450 mg. excipients: to 1 g.
Microcrystalline white powder.
Release Type:
Packages of polymeric film or foil laminated 100 g.
Type of drug:
Application:
Orally with water for the treatment and control of intestinal infections/ infestations
СOMPOSITION
1 g of the drug contains the active substance: piperazine citrate – 450 mg.
excipients: to 1 g.
DESCRIPTION
Microcrystalline white powder.
PHARMACOLOGICAL CHARACTERISTICS
The spectrum of activity of piperazine is largely against ascarid parasites in all animal species (including people). The safety margin is wide. Piperazine Citrate is an anthelmintic of low toxicity with a high efficiency against ascarids and some other nematodes.
Piperazine acts to block neuromuscular transmission in the parasite by hyperpolarizing the nerve membrane, which leads to flaccid paralysis. It also blocks succinate production by the worm. The parasites, paralysed and depleted of energy, are expelled by peristalsis. It is active against the ascarids Toxocara canis, Toxocara cati/ roundworm, Toxascaris leonine and hookworms. Piperazine is rapidly absorbed from the GI tract, and piperazine base can be detected in the urine as early as 30 minutes after administration. The excretion rate is maximal at 1 – 8hr, and excretion is practically complete within 24hrs.
DOSAGE
Orally with water for the treatment and control of intestinal infections/ infestations:
cattle, calves: neoascaridosis – 0.7 g/kg of body weight (once);
horses: parascaridosis, oxyuriasis – 0.7 g/kg of body weight (once);
dogs, cats and fur animals: toxocariasis, toxascaridosis, ancylostomiasis, uncinariasis – 0.2 g/kg of body weight (once);
rabbits (young): passalurosis – 0.1-0.2 g/kg of body weight (twice with an interval of 24 hours after a 18-24-hour starvation diet);
pigs: ascarosis, esophagostomiasis – 0.2 g/kg of body weight (twice with an interval of 24 hours during the morning feeding);
chickens, ducks, geese: ascaridiosis, ganguleterakidosis, amidostomosis, tetramerosis – 0.2 g / kg of body weight (twice with an interval of 24 hours).
CONTRAINDICATIONS
Do not apply to animals with hypersensitivity to piperazine, liver disease, kidney insufficiency.
PRECAUTIONS
Animals must not be
slaughtered for human consumption during treatment.
Animals may be slaughtered for human consumption only after 4 days from the last treatment.
Milk may be used for human consumption only after 24 hours from the last treatment
Received before this terms meat and eggs must be used to fed for unproductive animals or disposed in accordance with guidance from your local waste regulation authority.
STORAGE
Dry, dark place, away from children at the temperature from 10°C to 25°C.
Keep this product out of reach of children
SHELF-LIFE – 3 years from the date of manufacture.