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Piperazine 45% powder

1 g of the drug contains the active sub­stance: piperazine citrate – 450 mg. excipients: to 1 g.

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Microcrystalline white powder.


Release Type:


Packages of polymeric film or foil lami­nated 100 g.


Type of drug:


Application:


Orally with water for the treatment and control of intestinal infections/ infestations


СOMPOSITION

1 g of the drug contains the active sub­stance: piperazine citrate – 450 mg.

excipients: to 1 g.


DESCRIPTION

Microcrystalline white powder.


PHARMACOLOGICAL CHARACTERISTICS

The spectrum of activity of piperazine is largely against ascarid parasites in all animal species (including people). The safety margin is wide. Piperazine Citrate is an anthelmintic of low toxicity with a high efficiency against ascarids and some other nematodes.

Piperazine acts to block neuromuscular transmission in the parasite by hyperpolarizing the nerve membrane, which leads to flaccid paralysis. It also blocks succinate production by the worm. The parasites, paralysed and depleted of energy, are expelled by peristalsis. It is active against the ascarids Toxocara canis, Toxocara cati/ roundworm, Toxascaris leonine and hookworms. Piperazine is rapidly absorbed from the GI tract, and piperazine base can be detected in the urine as early as 30 minutes after administration. The excretion rate is maximal at 1 – 8hr, and excretion is practically complete within 24hrs.


DOSAGE 

 Orally with water for the treatment and control of intestinal infections/ infestations:

cattle, calves: neoascaridosis – 0.7 g/kg of body weight (once);

horses: parascaridosis, oxyuriasis – 0.7 g/kg of body weight (once);

dogs, cats and fur animals: toxocariasis, toxascaridosis, ancylostomiasis, uncinariasis – 0.2 g/kg of body weight (once);

rabbits (young): passalurosis – 0.1-0.2 g/kg of body weight (twice with an interval of 24 hours after a 18-24-hour starvation diet);

pigs: ascarosis, esophagostomiasis – 0.2 g/kg of body weight (twice with an interval of 24 hours during the morning feeding);

chickens, ducks, geese: ascaridiosis, ganguleterakidosis, amidostomosis, tetramerosis – 0.2 g / kg of body weight (twice with an interval of 24 hours).


CONTRAINDICATIONS

Do not apply to animals with hypersensitivity to piperazine, liver disease, kidney insufficiency.


PRECAUTIONS

 Animals must not be slaughtered for human consumption during treatment.
Animals may be slaughtered for human consumption only after 4 days from the last treatment.
 Milk  may be used  for human consumption only after 24 hours from the last treatment


Received before this terms meat and eggs  must be used to  fed  for unproductive animals or disposed  in accordance with guidance from your local waste regulation authority.


STORAGE

Dry, dark place, away from children at the temperature from 10°C to 25°C.


Keep this product out of reach of children


SHELF-LIFE – 3 years from the date of manufacture.